Integrative bioinformatics analysis of high-throughput sequencing and in vitro functional analysis leads to uncovering key hub genes in esophageal squamous cell carcinoma
COL3A1, COL4A1, COL5A2, and CXCL8 are crucial in ESCA development and progression, particularly in remodeling the extracellular matrix, modulating the immune system, and promoting metastasis. These findings suggest that these genes could serve as potential biomarkers for diagnosing ESCA and targets for future therapies. Future research should focus on in vivo validation of these findings and clinical testing to assess the therapeutic potential of targeting these genes in ESCA treatment.
Authors
- Lushan Cheng
- Zilong Zhao (ORCID: https://orcid.org/0000-0001-6607-4596)
- Chengbao Jing
- Hongyou Cao (ORCID: https://orcid.org/0000-0003-4891-1973)
- Ziquan Yu (ORCID: https://orcid.org/0000-0003-2411-2296)
- Feng Shen (ORCID: https://orcid.org/0000-0002-4172-457X)
- Xing Liu (ORCID: https://orcid.org/0000-0001-8152-6634)
- Jing Liu (ORCID: https://orcid.org/0000-0002-0958-5506)
- Fengjiao Ding (ORCID: https://orcid.org/0009-0006-3285-1047)
- Bing Zhao (ORCID: https://orcid.org/0000-0002-5562-0392)
- Xinyi Shi (ORCID: https://orcid.org/0000-0001-8739-1291)
- Xuewei Zhang (ORCID: https://orcid.org/0000-0003-4516-575X)
Institutions
- Ankang City Central Hospital (CN)
Publication Details
- Journal
- Hereditas
- Published
- 2025-03-14
- DOI
- https://doi.org/10.1186/s41065-025-00398-4
- Citations
- 1
- Primary Topic
- Esophageal Cancer Research and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 2.01