The impact of phthalates on asthma and chronic obstructive pulmonary disease: a comprehensive analysis based on network toxicology and molecular docking
Overall, this study highlights the harmful impacts of these seven phthalates on asthma and COPD, establishing new connections between the compounds and disease-related genes, and emphasizing their relevance as emerging environmental toxins. These findings provide valuable perspectives for risk assessment and public health policy, underscoring the need for stricter regulations and interventions regarding phthalate exposure.
Authors
- Jiayu Tian
- Lu He (ORCID: https://orcid.org/0000-0003-2749-7857)
- Xingyi Chen (ORCID: https://orcid.org/0009-0009-5626-8317)
- Huan Yang (ORCID: https://orcid.org/0000-0002-6262-9096)
- Linlin Guan (ORCID: https://orcid.org/0009-0000-9517-3171)
- Zhihong Zhang (ORCID: https://orcid.org/0000-0003-4458-1065)
- Yuqiong Zhang (ORCID: https://orcid.org/0000-0003-1444-7631)
- Li Ren (ORCID: https://orcid.org/0000-0002-5283-0300)
- Bingqing Zheng (ORCID: https://orcid.org/0000-0002-0472-0377)
- Cx Ren (ORCID: https://orcid.org/0000-0002-2914-7714)
- Dongxing Shi
- Lifang Zhao
Institutions
- Shanxi Medical University (CN)
Publication Details
- Journal
- Frontiers in Pharmacology
- Published
- 2025-03-14
- DOI
- https://doi.org/10.3389/fphar.2025.1566965
- Citations
- 1
- Primary Topic
- Effects and risks of endocrine disrupting chemicals
- Type
- article
- Field-Weighted Citation Impact
- 1.20