Development of Multiple Subcutaneous Lipomas After Six Months of Hormone Replacement Therapy: A Case Report

Lipomas are common benign soft tissue tumors composed of mature adipocytes, typically presenting as slow-growing, painless subcutaneous nodules. While the underlying etiology remains unclear, various factors have been proposed as potential contributors. In some individuals, multiple subcutaneous lipomas can develop, and their occurrence has been considered in relation to systemic conditions or familial predisposition. Hormone replacement therapy (HRT), commonly used for menopausal symptom management, influences lipid metabolism and angiogenesis through hormonal signaling pathways; however, its potential role in lipoma formation remains uncertain. Herein, we present a case of a 57-year-old woman who developed multiple subcutaneous lipomas on the thighs and buttocks after initiating HRT. This case highlights a possible association between hormonal changes and lipoma formation, emphasizing the importance of further research into the mechanisms underlying adipose tissue growth.