Metabolomic Profiles of Oral Rinse Samples to Distinguish Severe Periodontitis Patients From Non‐Periodontitis Controls
Our study demonstrates that simply collected oral rinse samples are suitable for LC-MS/MS based metabolomic analysis. We show that a metabolomic profile with a substantial number of metabolites can distinguish severe periodontitis patients from non-periodontitis controls. These observations can be a basis for further studies into screening to identify subjects with the risk of having severe periodontitis.
Authors
- Bruno G. Loos (ORCID: https://orcid.org/0000-0002-8794-552X)
- Martin Giera (ORCID: https://orcid.org/0000-0003-1684-1894)
- Jacques Neefjes (ORCID: https://orcid.org/0000-0001-6763-2211)
- Madeline X. F. Kosho (ORCID: https://orcid.org/0000-0001-7255-9645)
- Alessio Ciurli (ORCID: https://orcid.org/0000-0002-8550-5379)
Institutions
- Leiden University Medical Center (NL)
- Academic Center for Dentistry Amsterdam (NL)
- Netherlands Metabolomics Centre (NL)
- Oncode Institute (NL)
- Vrije Universiteit Amsterdam (NL)
- University of Amsterdam (NL)
Publication Details
- Journal
- Journal of Periodontal Research
- Published
- 2025-03-14
- DOI
- https://doi.org/10.1111/jre.13379
- Citations
- 3
- Primary Topic
- Oral microbiology and periodontitis research
- Type
- article
- Field-Weighted Citation Impact
- 4.40
Funders
- Philips Oral Healthcare