Serum Uromodulin as early marker for ischemic acute kidney injury and nephron loss: association with kidney tissue distribution pattern
In an AKI model with severe tubular damage, a transient increase in UMOD serum levels in parallel with loss of UMOD-positive cells suggests temporary release of UMOD from destroyed tubular cells into the blood. Serum UMOD appears to be not only a marker of chronic renal failure but also of acute loss of functional and cellular integrity of kidney epithelia in AKI.
Authors
- Nada Cordasic
- Maike Büttner‐Herold (ORCID: https://orcid.org/0000-0002-9974-6683)
- Nadja Ebert (ORCID: https://orcid.org/0000-0002-2361-6006)
- Anke Caroline Büttner (ORCID: https://orcid.org/0000-0001-7449-4777)
- Eva Vonbrunn (ORCID: https://orcid.org/0000-0003-0418-0267)
- Christoph Daniel (ORCID: https://orcid.org/0000-0002-6803-4755)
- Kerstin Amann
- Jürgen E. Scherberich
Institutions
- Friedrich-Alexander-Universität Erlangen-Nürnberg (DE)
- Universitätsklinikum Erlangen (DE)
- München Klinik Harlaching (DE)
- University of Birmingham (GB)
- Ludwig-Maximilians-Universität München (DE)
Publication Details
- Journal
- Journal of Translational Medicine
- Published
- 2025-03-14
- DOI
- https://doi.org/10.1186/s12967-025-06125-x
- Citations
- 4
- Primary Topic
- Acute Kidney Injury Research
- Type
- article
- Field-Weighted Citation Impact
- 5.72
Funders
- Deutsche Forschungsgemeinschaft
- Universitätsklinikum Erlangen