Targeting stemness pathways modulates macrophage polarization and reprograms the tumor microenvironment
Our study highlights the dual potential of stemness inhibitors to target both cancer cells and the immune microenvironment. These findings offer promising strategies for enhancing favorable immunomodulation in mesenchymal-like colorectal tumors.
Authors
- Agata Mlynska (ORCID: https://orcid.org/0000-0002-3646-0258)
- Adas Darinskas (ORCID: https://orcid.org/0000-0002-1916-7535)
- Vita Pašukonienė (ORCID: https://orcid.org/0000-0002-3395-1158)
- Austeja Butkute
- Marius Baltramonaitis
- Simona Malmige
Institutions
- Vilnius Gediminas Technical University (LT)
- Vilnius University (LT)
- National Cancer Institute (LT)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-03-14
- DOI
- https://doi.org/10.3389/fimmu.2025.1513404
- Citations
- 5
- Primary Topic
- Immune cells in cancer
- Type
- article
- Field-Weighted Citation Impact
- 3.99
Funders
- Lietuvos Mokslo Taryba