Exploring the application of single-step drying in lyophilization of high protein concentration formulations
Single-step drying was proved to be applicable to high protein concentration formulations with or without viscosity reducers. Significant cycle time reduction in drying process was achieved. Sublimation rate resulted in a more efficient drying cycle as a whole even though an increase of product resistance.
Authors
- Zhaowei Jin
- Jeremy Guo (ORCID: https://orcid.org/0000-0002-2497-9642)
- Qi Zeng
Institutions
- World Trade Organization (CH)
- WuXi AppTec (China) (CN)
Publication Details
- Journal
- Pharmaceutical Development and Technology
- Published
- 2025-03-14
- DOI
- https://doi.org/10.1080/10837450.2025.2476707
- Primary Topic
- Protein purification and stability
- Type
- article
- Field-Weighted Citation Impact
- 0.00