LXRα agonists ameliorates acute rejection after liver transplantation via ABCA1/MAPK and PI3K/AKT/mTOR signaling axis in macrophages
Our results suggest that the activation of LXRα can improve liver function and rat survival after LT by regulate ABCA1/MAPK and PI3K/AKT/mTOR signaling axis in macrophages.
Authors
- Zhongjun Wu (ORCID: https://orcid.org/0000-0002-1627-0633)
- Liangxu Wang (ORCID: https://orcid.org/0000-0002-1260-5838)
- Xiao‐Yan Qin (ORCID: https://orcid.org/0000-0001-8847-4267)
- Shiyi Zhang (ORCID: https://orcid.org/0000-0002-9375-5992)
- Dingheng Hu
- Qi Li (ORCID: https://orcid.org/0000-0002-7835-5886)
- Zheng Qin (ORCID: https://orcid.org/0000-0001-5645-5088)
- Rui Liao (ORCID: https://orcid.org/0000-0001-5155-9232)
- Yanyao Liu
Institutions
- China International Science and Technology Cooperation (CN)
- The Affiliated Yongchuan Hospital of Chongqing Medical University (CN)
- Children's Hospital of Chongqing Medical University (CN)
- Chongqing Medical University (CN)
Publication Details
- Journal
- Molecular Medicine
- Published
- 2025-03-14
- DOI
- https://doi.org/10.1186/s10020-025-01153-1
- Citations
- 5
- Primary Topic
- Cholesterol and Lipid Metabolism
- Type
- article
- Field-Weighted Citation Impact
- 10.03
Funders
- Chongqing Postdoctoral Science Foundation
- National Natural Science Foundation of China
- China Postdoctoral Science Foundation