Development of heart-sparing VMAT radiotherapy technique incorporating heart substructures for advanced NSCLC patients
Our analysis showed an improvement of dosimetric parameters of the heart and heart substructures in patients affected by locally advanced and centrally located NSCLC treated with curative RT using AHS optimization. This approach could lead to a possible reduction of heart events and a prolonged survival. New clinical studies regarding RT in advanced NSCLC should include cardiologic evaluations and biomarkers as well as the contouring of cardiac substructures.
Authors
- Sandra Ihne (ORCID: https://orcid.org/0000-0001-8540-7122)
- Ann-Katrin Exeli
- Daniel Habermehl (ORCID: https://orcid.org/0009-0007-7316-6422)
- Linda Agolli (ORCID: https://orcid.org/0000-0003-1534-4386)
- Uwe Schneider (ORCID: https://orcid.org/0000-0002-6403-204X)
- Andreas Lurtz
Institutions
- Lund University (SE)
- Justus-Liebig-Universität Gießen (DE)
- Universitätsklinikum Gießen und Marburg (DE)
- Universitätsklinikum Würzburg (DE)
Publication Details
- Journal
- Radiation Oncology
- Published
- 2025-03-14
- DOI
- https://doi.org/10.1186/s13014-025-02597-9
- Primary Topic
- Advanced Radiotherapy Techniques
- Type
- article
- Field-Weighted Citation Impact
- 0.00