Progressive Alcohol-Related Brain Atrophy and White Matter Pathology Are Linked to Long-Term Inhibitory Effects on mTOR Signaling
Short-term versus long-term ethanol exposures differentially altered white matter glial protein expression and signaling through mTOR's downstream mediators that have known roles in myelin maintenance. These findings suggest that strategic targeting of mTOR signaling dysregulation may be critical for maintaining the functional integrity of white matter and ultimately preventing long-term ARBD-related cognitive impairment.
Authors
- William Pelit (ORCID: https://orcid.org/0000-0002-7208-9986)
- Camilla Homans
- Suzanne M. de la Monte (ORCID: https://orcid.org/0000-0001-5886-2306)
- Büşra Delikkaya (ORCID: https://orcid.org/0009-0007-2967-6265)
- Ming Tong (ORCID: https://orcid.org/0000-0001-5927-5832)
Institutions
- Brown University (US)
- Rhode Island Hospital (US)
- Providence VA Medical Center (US)
Publication Details
- Journal
- Biomolecules
- Published
- 2025-03-14
- DOI
- https://doi.org/10.3390/biom15030413
- Citations
- 6
- Primary Topic
- Neuroinflammation and Neurodegeneration Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 5.05
Funders
- National Institute on Alcohol Abuse and Alcoholism