Activation of central and peripheral transient receptor potential melastatin 8 increases susceptibility to spreading depolarization and facilitates trigeminal neuroinflammation
TRPM8 activation increased susceptibility to SD and facilitated the effects of CGRP and trigeminal neuroinflammation, implicating that TRPM8 may contribute to migraine pathophysiology through central and peripheral mechanisms.
Authors
- Tzu-Ting Liu
- Taranov Ni
- Shuu‐Jiun Wang (ORCID: https://orcid.org/0000-0001-5179-5358)
- J Chen
- Pin‐Yu Chen (ORCID: https://orcid.org/0000-0003-1039-8369)
- Chih-Peng Tseng
- Y.-C. Chen
- Jiin‐Cherng Yen (ORCID: https://orcid.org/0000-0003-3667-822X)
- Shih‐Pin Chen (ORCID: https://orcid.org/0000-0003-3492-9902)
Institutions
- National Yang Ming Chiao Tung University (TW)
- Taipei Veterans General Hospital (TW)
Publication Details
- Journal
- The Journal of Headache and Pain
- Published
- 2025-03-14
- DOI
- https://doi.org/10.1186/s10194-025-01997-2
- Citations
- 3
- Primary Topic
- Ion Channels and Receptors
- Type
- article
- Field-Weighted Citation Impact
- 4.39
Funders
- Taipei Veterans General Hospital