Alteration in ATR protein level does not account for the inherent radiosensitivity of HPV-positive head and neck squamous cell carcinoma
Since the effect of ATRKD was compensated in HPV-negative but not in HPV-positive cells, these data revealed that the two-fold lower level of ATR in HPV-positive cells does not account for their enhanced inherent radiosensitivity, but acts additive to irradiation.
Authors
- Ulrike Schötz (ORCID: https://orcid.org/0000-0001-8118-3977)
- Ann Christin Parplys (ORCID: https://orcid.org/0000-0002-8578-9957)
- Florentine S. B. Subtil
- Vanessa Climenti
- Sibylla Kohl
- Sebastian Adeberg (ORCID: https://orcid.org/0000-0001-8463-514X)
- Rita Engenhart‐Cabillic (ORCID: https://orcid.org/0000-0002-7444-9033)
- Ekkehard Dikomey
- Houmam Anees (ORCID: https://orcid.org/0009-0002-2427-0841)
Institutions
- Universität Hamburg (DE)
- Philipps University of Marburg (DE)
- University Medical Center Hamburg-Eppendorf (DE)
Publication Details
- Journal
- Translational Oncology
- Published
- 2025-03-14
- DOI
- https://doi.org/10.1016/j.tranon.2025.102359
- Primary Topic
- Genetics and Neurodevelopmental Disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Anneliese Pohl Stiftung