Impact of Antibiotic Duration on Gut Microbiome Composition and Antimicrobial Resistance: A Substudy of the BALANCE Randomized Controlled Trial

In this subset of patients from the BALANCE randomized controlled trial, we did not detect greater gut microbiome disruption or ARG carriage among participants who received 14 vs 7 days of antibiotics, but we were limited by small sample size and imbalances between groups.

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Publication Details

Journal
Open Forum Infectious Diseases
Published
2025-02-28
DOI
https://doi.org/10.1093/ofid/ofaf137
Citations
2
Primary Topic
Gut microbiota and health
Type
article
Field-Weighted Citation Impact
1.61
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article

Impact of Antibiotic Duration on Gut Microbiome Composition and Antimicrobial Resistance: A Substudy of the BALANCE Randomized Controlled Trial

Gerald A. Evans, Jan O. Friedrich, Rob Fowler, Bryan A. Coburn et al.
2 citations
Open Forum Infectious Diseases
Gut microbiota and health
1.61
article

Impact of Antibiotic Duration on Gut Microbiome Composition and Antimicrobial Resistance: A Substudy of the BALANCE Randomized Controlled Trial

Gerald A. Evans, Jan O. Friedrich, Rob Fowler, Bryan A. Coburn, Eric Armstrong, Linda R. Taggart, Jennifer Tsang, Michael E. Detsky, Maria Kulikova, John Muscedere, Erick Duan, David M. Maslove, John C. Marshall, Stephanie Sibley, Aidan Findlater, David J. McCullagh, J. Gordon Boyd, N. Yee, Asgar Rishu, Nick Daneman, Karim Ali Firdous
article en
2 citations

Abstract

In this subset of patients from the BALANCE randomized controlled trial, we did not detect greater gut microbiome disruption or ARG carriage among participants who received 14 vs 7 days of antibiotics, but we were limited by small sample size and imbalances between groups.

Open Forum Infectious DiseasesVol. 12(3)
Health Canada (CA), Mount Sinai Hospital (CA), St. Michael's Hospital (CA), Sunnybrook Health Science Centre (CA), University Health Network (CA), Toronto Public Health (CA), University of Toronto (CA), Queen's University (CA), Toronto General Hospital (CA), Health Sciences Centre (CA), Niagara Health System (CA), St Michael’s Hospital (IE), Toronto General Hospital Research Institute, McMaster University (CA)
Openalex Percentile: Top 19%
Gut microbiota and health
1.61
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