Impact of Antibiotic Duration on Gut Microbiome Composition and Antimicrobial Resistance: A Substudy of the BALANCE Randomized Controlled Trial
In this subset of patients from the BALANCE randomized controlled trial, we did not detect greater gut microbiome disruption or ARG carriage among participants who received 14 vs 7 days of antibiotics, but we were limited by small sample size and imbalances between groups.
Authors
- Gerald A. Evans (ORCID: https://orcid.org/0000-0003-2557-0897)
- Jan O. Friedrich (ORCID: https://orcid.org/0000-0001-7248-2350)
- Rob Fowler
- Bryan A. Coburn (ORCID: https://orcid.org/0000-0003-0150-4510)
- Eric Armstrong (ORCID: https://orcid.org/0000-0002-4530-6631)
- Linda R. Taggart
- Jennifer Tsang (ORCID: https://orcid.org/0000-0002-1809-0505)
- Michael E. Detsky (ORCID: https://orcid.org/0000-0001-8305-2137)
- Maria Kulikova (ORCID: https://orcid.org/0000-0001-5107-8834)
- John Muscedere
- Erick Duan (ORCID: https://orcid.org/0009-0008-3573-7754)
- David M. Maslove (ORCID: https://orcid.org/0000-0002-0765-7158)
- John C. Marshall (ORCID: https://orcid.org/0000-0002-7902-6291)
- Stephanie Sibley (ORCID: https://orcid.org/0000-0003-2229-9747)
- Aidan Findlater (ORCID: https://orcid.org/0000-0003-4698-7536)
- David J. McCullagh
- J. Gordon Boyd (ORCID: https://orcid.org/0000-0002-9522-2364)
- N. Yee (ORCID: https://orcid.org/0009-0002-1817-5768)
- Asgar Rishu
- Nick Daneman
- Karim Ali Firdous
Institutions
- Health Canada (CA)
- Mount Sinai Hospital (CA)
- St. Michael's Hospital (CA)
- Sunnybrook Health Science Centre (CA)
- University Health Network (CA)
- Toronto Public Health (CA)
- University of Toronto (CA)
- Queen's University (CA)
- Toronto General Hospital (CA)
- Health Sciences Centre (CA)
- Niagara Health System (CA)
- St Michael’s Hospital (IE)
- Toronto General Hospital Research Institute
- McMaster University (CA)
Publication Details
- Journal
- Open Forum Infectious Diseases
- Published
- 2025-02-28
- DOI
- https://doi.org/10.1093/ofid/ofaf137
- Citations
- 2
- Primary Topic
- Gut microbiota and health
- Type
- article
- Field-Weighted Citation Impact
- 1.61