KAT7 contributes to ponatinib-induced hypertension by promoting endothelial senescence and inflammatory responses through activating NF-κB signaling pathway
Our data indicate that ponatinib-induced elevation of KAT7 led to endothelial cells senescence and inflammatory responses through H3K14 acetylation and NF-κB signaling pathway, subsequently caused vasotoxicity and hypertension.
Authors
- Xinyu Xu (ORCID: https://orcid.org/0000-0003-3997-012X)
- Chen Liang (ORCID: https://orcid.org/0000-0003-0578-7589)
- Liang‐Liang Tang
- Shuai Jiang (ORCID: https://orcid.org/0000-0002-6083-9081)
- Changjiang Yu (ORCID: https://orcid.org/0000-0001-6395-5814)
- Qiushi Wang (ORCID: https://orcid.org/0000-0001-7678-6941)
- Rong Xue (ORCID: https://orcid.org/0009-0009-8734-8440)
- Zhi‐Ren Zhang (ORCID: https://orcid.org/0000-0003-1324-6934)
- Xu Yang (ORCID: https://orcid.org/0000-0003-2242-670X)
- Qi Qin (ORCID: https://orcid.org/0000-0003-2349-6355)
- Mei Zhang (ORCID: https://orcid.org/0000-0003-2717-7167)
Institutions
- Harbin Medical University (CN)
- Heilongjiang Academy of Sciences (CN)
Publication Details
- Journal
- Journal of Hypertension
- Published
- 2025-03-07
- DOI
- https://doi.org/10.1097/hjh.0000000000003979
- Citations
- 5
- Primary Topic
- Immune cells in cancer
- Type
- article
- Field-Weighted Citation Impact
- 3.99