Bacterial translocation and gut microbiome imbalance in an experimental infection model of legionellosis in guinea pigs
Infection with the Legionella pneumophila serotype 1 disrupted the intestinal microbiota in a subset of guinea pigs during a 72-hour period post-infection, with possible translocation of gut-associated anaerobic bacteria to the lungs and liver based on the presence of genomic DNA detected in tissue from infected guinea pigs.
Authors
- Ye Lu (ORCID: https://orcid.org/0000-0002-8729-0316)
- Wei Wang (ORCID: https://orcid.org/0000-0001-6777-2441)
- Jian Kang (ORCID: https://orcid.org/0000-0002-8697-0993)
- Wei Shen (ORCID: https://orcid.org/0000-0002-3779-0451)
- Yu Chen (ORCID: https://orcid.org/0000-0001-9767-4797)
- Xu Cai (ORCID: https://orcid.org/0000-0001-5675-5638)
- Mingtao Xu
Institutions
- Harbin Medical University (CN)
- Fourth Affiliated Hospital of Harbin Medical University (CN)
- Heilongjiang Provincial Hospital (CN)
- First Hospital of China Medical University (CN)
- China Medical University (CN)
Publication Details
- Journal
- BMC Microbiology
- Published
- 2025-03-14
- DOI
- https://doi.org/10.1186/s12866-025-03845-4
- Citations
- 1
- Primary Topic
- Gut microbiota and health
- Type
- article
- Field-Weighted Citation Impact
- 0.81
Funders
- National Natural Science Foundation of China
- National Key Research and Development Program of China