Cover Feature: Target Identification of Marine Natural Product Odoamide:Odoamide Induces Apoptotic Cell Death by Targeting ATPase Na⁺/K⁺ Transporting Subunit Alpha 1 (ATP1A1) (ChemBioChem 6/2025)

Odoamide, a member of aurilide-family, exhibits highly potent cytotoxicity against cancer cells lines. The background scenery is Odohama Beach in Okinawa, Japan, where odoamide was isolated. Three key points are shown above: affinity-based target identification, the target protein, and phenotype of cytotoxicity. These findings will provide target identification technologies and critical information on the subsequent mechanistic analysis as well, which has been under discussion for years. More details can be found in article 10.1002/cbic.202400762 by Ryosuke Katsumata, Hiroshi Kamiyama, Yasutaka Takase, and co-workers.