Gut Microbiome dysbiosis and immune activation correlate with somatic and neuropsychiatric symptoms in COVID-19 patients
Our findings reveal significant associations between mental health status, systemic inflammation, and gut dysbiosis in hospitalized COVID-19 patients. These results indicate the potential for microbiome-targeted therapies to mitigate psychological and physical complications and improve recovery outcomes in this population.
Authors
- Paula Luciana Scalzo (ORCID: https://orcid.org/0000-0003-1383-8550)
- Mario F. Dulay (ORCID: https://orcid.org/0009-0003-5530-6461)
- Sonia Villapol (ORCID: https://orcid.org/0000-0002-6174-4113)
- Austin Marshall (ORCID: https://orcid.org/0000-0001-5749-1558)
- Eamonn M.M. Quigley (ORCID: https://orcid.org/0000-0003-4151-7180)
- Timea Hodics (ORCID: https://orcid.org/0000-0001-8957-7807)
- Sirena Soriano (ORCID: https://orcid.org/0000-0001-9967-7262)
- María Piskorz (ORCID: https://orcid.org/0000-0001-8616-3457)
- Todd J. Treangen (ORCID: https://orcid.org/0000-0002-3760-564X)
- Kristen Curry (ORCID: https://orcid.org/0000-0001-8375-397X)
Institutions
- Universidade Federal de Minas Gerais (BR)
- Houston Methodist (US)
- Institut Pasteur (FR)
- Université Paris Cité (FR)
- Cornell University (US)
- Universidad de Buenos Aires (AR)
- Methodist Hospital (US)
- Hospital de Clínicas "José de San Martín" (AR)
- Rice University (US)
Publication Details
- Journal
- Journal of Translational Medicine
- Published
- 2025-03-14
- DOI
- https://doi.org/10.1186/s12967-025-06348-y
- Citations
- 6
- Primary Topic
- Tryptophan and brain disorders
- Type
- article
- Field-Weighted Citation Impact
- 3.47
Funders
- National Institute on Aging
- National Institute of Neurological Disorders and Stroke