Macrophage-derived SPP1 exacerbate myocardial injury by interacting with fibroblasts in viral myocarditis
Our findings suggested that Spp1<sup>+</sup> macrophages could self-recruit, and macrophage-derived SPP1 exacerbated myocardial immune injury by promoting high Ccl2/Ccl7 expression in fibroblasts. Our study advances understandings of VMC pathogenesis, and provides novel insight into potential immunotherapies for VMC.
Authors
- Shan Zhou (ORCID: https://orcid.org/0000-0001-9067-6802)
- Bo Han (ORCID: https://orcid.org/0000-0001-5286-372X)
- Xiuyun Duan
- Yingnan You (ORCID: https://orcid.org/0009-0005-5139-2977)
- Hailin Jia (ORCID: https://orcid.org/0000-0002-4051-1089)
- Kaiyin Guo
- Zhang Li (ORCID: https://orcid.org/0000-0003-4823-7480)
- Keyu Liu (ORCID: https://orcid.org/0000-0002-8429-8267)
Institutions
- Shandong University (CN)
- Shandong Provincial Hospital (CN)
- Shanghai Institute of Hematology (CN)
- Shandong First Medical University (CN)
Publication Details
- Journal
- Biology Direct
- Published
- 2025-03-14
- DOI
- https://doi.org/10.1186/s13062-025-00621-2
- Citations
- 9
- Primary Topic
- Viral Infections and Immunology Research
- Type
- article
- Field-Weighted Citation Impact
- 12.49
Funders
- Jinan Science and Technology Bureau
- Taishan Scholar Foundation of Shandong Province
- Natural Science Foundation of Shandong Province