A single-nucleus and spatial transcriptomic atlas of the COVID-19 liver reveals topological, functional, and regenerative organ disruption in patients
Our atlas provides novel insights into liver physiology and pathology in COVID-19 and forms a foundational resource for its investigation and understanding.
Authors
- Alexander Sturm (ORCID: https://orcid.org/0000-0002-3818-0428)
- Devan Phillips (ORCID: https://orcid.org/0000-0002-9240-4912)
- Sebastian Niezen (ORCID: https://orcid.org/0000-0002-9297-8828)
- Aviv Regev (ORCID: https://orcid.org/0000-0003-3293-3158)
- Victoria M. Tran (ORCID: https://orcid.org/0000-0002-7718-5889)
- Gyöngyi Szabó (ORCID: https://orcid.org/0000-0003-0836-2527)
- Jana Biermann (ORCID: https://orcid.org/0000-0002-8907-4633)
- Amit Dipak Amin (ORCID: https://orcid.org/0000-0002-2613-2082)
- Gary D. Bader (ORCID: https://orcid.org/0000-0003-0185-8861)
- Yan Liang (ORCID: https://orcid.org/0000-0002-8536-5951)
- Andriy Myloserdnyy
- Eric Miller (ORCID: https://orcid.org/0000-0002-3243-4968)
- Dimitra Karagkouni (ORCID: https://orcid.org/0009-0007-3961-3399)
- Robert F. Padera (ORCID: https://orcid.org/0000-0002-4571-5494)
- Stephen J. Fleming (ORCID: https://orcid.org/0000-0002-1885-4405)
- Olga R. Brook (ORCID: https://orcid.org/0000-0002-7074-8909)
- James Gomez (ORCID: https://orcid.org/0000-0002-2640-7453)
- Caroline Porter (ORCID: https://orcid.org/0000-0001-8294-5232)
- Orr Ashenberg (ORCID: https://orcid.org/0000-0002-7802-8834)
- Linus Tsai (ORCID: https://orcid.org/0000-0002-0134-6949)
- Andy Nam (ORCID: https://orcid.org/0000-0003-1857-2245)
- Ayshwarya Subramanian (ORCID: https://orcid.org/0000-0002-4134-7612)
- Molly Veregge (ORCID: https://orcid.org/0009-0004-9455-4166)
- Stefan Riedel (ORCID: https://orcid.org/0000-0002-0573-4957)
- Deborah T. Hung (ORCID: https://orcid.org/0000-0003-4262-0673)
- Adam L. Essene
- Mark Gregory (ORCID: https://orcid.org/0000-0003-4149-4724)
- Z. Gordon Jiang (ORCID: https://orcid.org/0009-0007-0801-668X)
- Ioannis S. Vlachos (ORCID: https://orcid.org/0000-0002-8849-808X)
- Johannes C. Melms (ORCID: https://orcid.org/0000-0002-5410-6586)
- Tallulah Andrews (ORCID: https://orcid.org/0000-0003-1120-2196)
- Disha Skelton-Badlani
- Alexandra–Chloé Villani (ORCID: https://orcid.org/0000-0001-7461-0408)
- Tyler Hether (ORCID: https://orcid.org/0000-0002-4074-9003)
- Benjamin Izar (ORCID: https://orcid.org/0000-0003-2379-6702)
- Deepti Pant (ORCID: https://orcid.org/0000-0002-6890-081X)
- Sonya A. MacParland (ORCID: https://orcid.org/0000-0002-8036-1425)
- Shanshan He
- Joseph Beechem (ORCID: https://orcid.org/0000-0001-8372-5899)
- Orit Rozenblatt–Rosen (ORCID: https://orcid.org/0000-0001-6313-3570)
- Carly G.K. Ziegler (ORCID: https://orcid.org/0000-0002-8279-7150)
- Zachary Kramer (ORCID: https://orcid.org/0000-0002-6726-2246)
- Yury V. Popov (ORCID: https://orcid.org/0000-0001-7973-942X)
- Jonathan L. Hecht (ORCID: https://orcid.org/0000-0003-4771-2585)
- Zohar Bloom‐Ackermann (ORCID: https://orcid.org/0000-0001-9149-4218)
- Yered Pita-Juárez (ORCID: https://orcid.org/0000-0001-6992-252X)
- Nikolaos Kalavros (ORCID: https://orcid.org/0000-0001-5503-9808)
- Michal Slyper (ORCID: https://orcid.org/0000-0002-3002-0366)
- Toni Delorey (ORCID: https://orcid.org/0000-0001-6614-3803)
- Liuliu Pan
- Pinzhu Huang (ORCID: https://orcid.org/0000-0002-8339-9701)
- Pourya Naderi Yeganeh (ORCID: https://orcid.org/0000-0002-4693-8331)
- Sarah Warren (ORCID: https://orcid.org/0000-0001-9465-8636)
- Alex K. Shalek (ORCID: https://orcid.org/0000-0001-5670-8778)
- Michael J. Patrick
- Mehrtash Babadi (ORCID: https://orcid.org/0000-0003-1829-8397)
- Hanina Hibshoosh (ORCID: https://orcid.org/0000-0001-9688-4514)
- Yusuf Yalcin (ORCID: https://orcid.org/0000-0001-5571-4842)
- Christopher Jacobs (ORCID: https://orcid.org/0000-0002-6034-1873)
- Tushar D. Rane (ORCID: https://orcid.org/0000-0002-5446-4164)
- Isaac H. Solomon (ORCID: https://orcid.org/0000-0003-3432-0902)
- Rachel Chen (ORCID: https://orcid.org/0000-0001-8361-729X)
- Shuting Zhang (ORCID: https://orcid.org/0000-0001-9140-8893)
- Jason Reeves (ORCID: https://orcid.org/0000-0003-0685-9644)
- Stefan Phelan
- Aster Wardhani
- Nasser Imad
Institutions
- Broad Institute (US)
- Brigham and Women's Hospital (US)
- Beth Israel Deaconess Medical Center (US)
- University Health Network (CA)
- Harvard University (US)
- Cancer Research Institute (US)
- University of Toronto (CA)
- Columbia University Irving Medical Center (US)
- Harvard University Press (US)
- Canada Research Chairs (CA)
- Ragon Institute of MGH, MIT and Harvard (US)
- Massachusetts General Hospital (US)
- HES-SO Genève (CH)
- Harvard Affiliated Emergency Medicine Residency (US)
- Harvard–MIT Division of Health Sciences and Technology (US)
- Nanostring Technologies (United States) (US)
- IIT@MIT (US)
- Center for Cancer Research (US)
- Harvard Stem Cell Institute (US)
- Massachusetts Institute of Technology (US)
Publication Details
- Journal
- Genome biology
- Published
- 2025-03-14
- DOI
- https://doi.org/10.1186/s13059-025-03499-5
- Citations
- 6
- Primary Topic
- Single-cell and spatial transcriptomics
- Type
- article
- Field-Weighted Citation Impact
- 4.03
Funders
- Bill and Melinda Gates Foundation
- U.S. Food and Drug Administration
- National Cancer Institute
- Office of Research Infrastructure Programs, National Institutes of Health