A single-nucleus and spatial transcriptomic atlas of the COVID-19 liver reveals topological, functional, and regenerative organ disruption in patients

Our atlas provides novel insights into liver physiology and pathology in COVID-19 and forms a foundational resource for its investigation and understanding.

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Publication Details

Journal
Genome biology
Published
2025-03-14
DOI
https://doi.org/10.1186/s13059-025-03499-5
Citations
6
Primary Topic
Single-cell and spatial transcriptomics
Type
article
Field-Weighted Citation Impact
4.03

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article

A single-nucleus and spatial transcriptomic atlas of the COVID-19 liver reveals topological, functional, and regenerative organ disruption in patients

Alexander Sturm, Devan Phillips, Sebastian Niezen, Aviv Regev et al.
6 citations
Genome biology
Single-cell and spatial transcriptomics
4.03
article

A single-nucleus and spatial transcriptomic atlas of the COVID-19 liver reveals topological, functional, and regenerative organ disruption in patients

Alexander Sturm, Devan Phillips, Sebastian Niezen, Aviv Regev, Victoria M. Tran, Gyöngyi Szabó, Jana Biermann, Amit Dipak Amin, Gary D. Bader, Yan Liang, Andriy Myloserdnyy, Eric Miller, Dimitra Karagkouni, Robert F. Padera, Stephen J. Fleming, Olga R. Brook, James Gomez, Caroline Porter, Orr Ashenberg, Linus Tsai, Andy Nam, Ayshwarya Subramanian, Molly Veregge, Stefan Riedel, Deborah T. Hung, Adam L. Essene, Mark Gregory, Z. Gordon Jiang, Ioannis S. Vlachos, Johannes C. Melms, Tallulah Andrews, Disha Skelton-Badlani, Alexandra–Chloé Villani, Tyler Hether, Benjamin Izar, Deepti Pant, Sonya A. MacParland, Shanshan He, Joseph Beechem, Orit Rozenblatt–Rosen, Carly G.K. Ziegler, Zachary Kramer, Yury V. Popov, Jonathan L. Hecht, Zohar Bloom‐Ackermann, Yered Pita-Juárez, Nikolaos Kalavros, Michal Slyper, Toni Delorey, Liuliu Pan, Pinzhu Huang, Pourya Naderi Yeganeh, Sarah Warren, Alex K. Shalek, Michael J. Patrick, Mehrtash Babadi, Hanina Hibshoosh, Yusuf Yalcin, Christopher Jacobs, Tushar D. Rane, Isaac H. Solomon, Rachel Chen, Shuting Zhang, Jason Reeves, Stefan Phelan, Aster Wardhani, Nasser Imad
article en
6 citations

Abstract

Our atlas provides novel insights into liver physiology and pathology in COVID-19 and forms a foundational resource for its investigation and understanding.

Genome biologyVol. 26(1)
Broad Institute (US), Brigham and Women's Hospital (US), Beth Israel Deaconess Medical Center (US), University Health Network (CA), Harvard University (US), Cancer Research Institute (US), University of Toronto (CA), Columbia University Irving Medical Center (US), Harvard University Press (US), Canada Research Chairs (CA), Ragon Institute of MGH, MIT and Harvard (US), Massachusetts General Hospital (US), HES-SO Genève (CH), Harvard Affiliated Emergency Medicine Residency (US), Harvard–MIT Division of Health Sciences and Technology (US), Nanostring Technologies (United States) (US), IIT@MIT (US), Center for Cancer Research (US), Harvard Stem Cell Institute (US), Massachusetts Institute of Technology (US)
Bill and Melinda Gates Foundation, U.S. Food and Drug Administration, National Cancer Institute, Office of Research Infrastructure Programs, National Institutes of Health
Openalex Percentile: Top 7%
Single-cell and spatial transcriptomics
4.03
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