Multiple insecticide resistance in Anopheles funestus from Mopeia, Central Mozambique
Malaria vectors in Mopeia exhibit resistance to all four major public health insecticide classes: pyrethroids, organophosphates, organochlorides and carbamates. This highlights the urgent need to adopt new insecticide classes for vector control interventions. The partial restoration of susceptibility by PBO suggests resistance is being driven by various mechanisms including the involvement of metabolic resistance through cytochrome P450 monooxygenase enzymes and glutathione S-transferases.
Authors
- Luis Miguel Constantino (ORCID: https://orcid.org/0000-0001-8117-5803)
- Carlos Chaccour (ORCID: https://orcid.org/0000-0001-9812-050X)
- Francisco Saúte (ORCID: https://orcid.org/0000-0002-9107-8094)
- Jonathan Karisa (ORCID: https://orcid.org/0000-0002-3383-6782)
- Caroline Wanjiku (ORCID: https://orcid.org/0000-0003-3861-4190)
- Caroline Kiuru (ORCID: https://orcid.org/0000-0002-0179-5322)
- N. Regina Rabinovich
- Baltazar Candrinho (ORCID: https://orcid.org/0000-0001-7373-6631)
- Marta F. Maia (ORCID: https://orcid.org/0000-0003-3302-5610)
- Gildo Cole
- Miguel Okoko
Institutions
- Kenya Medical Research Institute (KE)
- University of Oxford (GB)
- Centro de Investigación Biomédica en Red (ES)
- Manhiça Health Research Centre (MZ)
- Barcelona Institute for Global Health (ES)
- Ministry of Health (MZ)
- Universidad de Navarra (ES)
Publication Details
- Journal
- Malaria Journal
- Published
- 2025-03-14
- DOI
- https://doi.org/10.1186/s12936-025-05321-w
- Citations
- 4
- Primary Topic
- Insect Resistance and Genetics
- Type
- article
- Field-Weighted Citation Impact
- 3.22