Apoptotic cell-derived extracellular vesicles-MTA1 confer radioresistance in cervical cancer by inducing cellular dormancy
This study demonstrates that apoEV-MTA1 confers radioresistance in CC by promoting cellular dormancy via the p-STAT1/NR2F1 signaling axis. Targeting this pathway could improve radiosensitivity and provide a promising therapeutic strategy for CC patients.
Authors
- Huiping Jiang (ORCID: https://orcid.org/0000-0001-9539-1662)
- Shaocheng Chen (ORCID: https://orcid.org/0009-0007-0327-0988)
- Cai-Qiu Xu (ORCID: https://orcid.org/0000-0002-6892-3675)
- Suiqun Guo
- Jing Fan (ORCID: https://orcid.org/0000-0001-8297-6522)
- Xiaojing Chen (ORCID: https://orcid.org/0000-0002-5652-3834)
- Wan Zhang (ORCID: https://orcid.org/0000-0001-7052-5441)
- Qiao-Zhi Wu
- Yuan-Run Deng
Institutions
- Third Affiliated Hospital of Southern Medical University (CN)
- Nanfang Hospital (CN)
- Dongguan People’s Hospital (CN)
- Guangdong Academy of Medical Sciences (CN)
- Guangdong Provincial People's Hospital (CN)
- Southern Medical University (CN)
Publication Details
- Journal
- Journal of Translational Medicine
- Published
- 2025-03-14
- DOI
- https://doi.org/10.1186/s12967-025-06350-4
- Citations
- 6
- Primary Topic
- Extracellular vesicles in disease
- Type
- article
- Field-Weighted Citation Impact
- 4.84
Funders
- National Natural Science Foundation of China