Plasma Potassium Negatively Correlates With Sodium Chloride Cotransporter Abundance and Phosphorylation in Urinary Extracellular Vesicles From Patients With Chronic Kidney Disease
In patients with CKD, there are negative correlations between NCC and pNCC in uEVs and plasma potassium, which appear independent of eGFR. This suggests that the mechanism at play is distinct from the overall kidney function, and potassium supplement within a safe level may assist in natriuresis and improve cardiovascular outcomes.
Authors
- Martin Wolley (ORCID: https://orcid.org/0000-0002-7870-5073)
- David A. Vesey (ORCID: https://orcid.org/0000-0002-2856-6650)
- Andrew Scott Terker (ORCID: https://orcid.org/0000-0003-1498-9043)
- Paul A. Welling (ORCID: https://orcid.org/0000-0002-0719-8705)
- M. Stowasser
- Robert A. Fenton (ORCID: https://orcid.org/0000-0003-1623-199X)
- Aihua Wu (ORCID: https://orcid.org/0000-0001-9610-0943)
Institutions
- Translational Research Institute (AU)
- Johns Hopkins University (US)
- The University of Queensland (AU)
- Aarhus University (DK)
- Royal Brisbane and Women's Hospital (AU)
- Johns Hopkins Medicine (US)
- Princess Alexandra Hospital (AU)
- Vanderbilt University Medical Center (US)
Publication Details
- Journal
- Nephrology
- Published
- 2025-03-01
- DOI
- https://doi.org/10.1111/nep.70017
- Primary Topic
- Sodium Intake and Health
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Fondation Leducq
- Queensland University of Technology