Blocking ITGA5 potentiates the efficacy of anti‐PD‐1 therapy on glioblastoma by remodeling tumor‐associated macrophages
This work elucidated the potential tissue adaptation mechanism of intratumoral dynamic interactions between MES-GBM cells, MDMs and T cells in anti-PD-1 non-responders and identified the therapeutic potential of targeting ITGA5 to reduce anti-PD-1 resistance in GBM.
Authors
- Hao Xue
- Yanhua Qi (ORCID: https://orcid.org/0000-0001-5821-7550)
- Xiaofan Guo (ORCID: https://orcid.org/0000-0002-7220-5094)
- Zijie Gao (ORCID: https://orcid.org/0009-0002-8974-5633)
- Gang Li (ORCID: https://orcid.org/0000-0001-7787-9330)
- Linhong Deng (ORCID: https://orcid.org/0000-0003-1970-8239)
- Boyan Li (ORCID: https://orcid.org/0009-0009-6271-9858)
- Rongrong Zhao
- Wei Qiu (ORCID: https://orcid.org/0000-0002-0188-4931)
- Ziwen Pan (ORCID: https://orcid.org/0000-0003-4830-126X)
- Jiawei Qiu
- Weijie Tang
Institutions
- Allen Institute for Brain Science (US)
- Shandong University (CN)
- Loma Linda University Health Care (US)
- Qilu Hospital of Shandong University (CN)
Publication Details
- Journal
- Cancer Communications
- Published
- 2025-03-14
- DOI
- https://doi.org/10.1002/cac2.70016
- Citations
- 16
- Primary Topic
- Circular RNAs in diseases
- Type
- article
- Field-Weighted Citation Impact
- 12.90
Funders
- National Natural Science Foundation of China
- Fundamental Research Funds for the Central Universities