γ-Mangostin mitigates impaired wound healing and pyroptosis in human gingival fibroblasts induced by advanced glycation end products
Our findings suggest that AGEs impair wound healing and promote oxidative stress, cellular senescence, pyroptosis, and inflammation. γ-Mangostin treatment mitigated these effects, potentially by attenuating inflammation and pyroptosis, thereby improving wound healing.
Authors
- Cheng‐Chia Yu (ORCID: https://orcid.org/0000-0002-2720-3145)
- Chao-Yen Huang
- Szu-Han Chen
- Pei‐Yin Chen (ORCID: https://orcid.org/0000-0002-5104-6055)
- Yi‐Wen Liao
- Min Yee Ng
Institutions
- Chung Shan Medical University Hospital (TW)
- Chung Shan Medical University (TW)
Publication Details
- Journal
- Journal of Dental Sciences
- Published
- 2025-03-14
- DOI
- https://doi.org/10.1016/j.jds.2025.03.001
- Primary Topic
- Advanced Glycation End Products research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Chung Shan Medical University Hospital