Real-world pharmacokinetics of elexacaftor-tezacaftor-ivacaftor in children with cystic fibrosis: a prospective observational study
This study is the first analysis of ETI popPK in cwCF. The developed popPK models may be used to further study the exposure-response relationship and its variability within cwCF, as a basis for more personalized dosing.
Authors
- Simone Hashimoto (ORCID: https://orcid.org/0000-0001-8995-3817)
- Suzanne W. J. Terheggen‐Lagro (ORCID: https://orcid.org/0000-0002-3305-3745)
- Anke H. Maitland‐van der Zee (ORCID: https://orcid.org/0000-0002-0414-3442)
- E. Marleen Kemper (ORCID: https://orcid.org/0000-0003-2275-1713)
- Ron A. A. Mathôt (ORCID: https://orcid.org/0000-0001-8401-0879)
- Steffie E. M. Vonk (ORCID: https://orcid.org/0000-0001-9905-7805)
- Eric G. Haarman (ORCID: https://orcid.org/0000-0003-1303-1423)
Institutions
- University of Amsterdam (NL)
Publication Details
- Journal
- Journal of Cystic Fibrosis
- Published
- 2025-03-14
- DOI
- https://doi.org/10.1016/j.jcf.2025.03.008
- Citations
- 5
- Primary Topic
- Cystic Fibrosis Research Advances
- Type
- article
- Field-Weighted Citation Impact
- 7.59