Impact of biological and genetic features of leukemic cells on the occurrence of “shark fins” in the WPC channel scattergrams of the Sysmex XN hematology analyzers in patients with chronic lymphocytic leukemia
We identified the lymphocyte count, the absence of TP53 mutations and del(17p), a mutated IGHV and the proportion of smudge cells as significant influences on the appearance of "shark fin" cells. Our findings indicate an impact of biological and genetic properties of the leukemic cells on the formation of "shark fins".
Authors
- Franz Quehenberger (ORCID: https://orcid.org/0000-0003-0764-9497)
- Margot Egger
- Christoph Robier (ORCID: https://orcid.org/0000-0002-8993-7507)
- I-Fei Fang
Institutions
- Johannes Kepler University of Linz (AT)
- Medical University of Graz (AT)
- Convent Hospital of the Brothers of Saint John of God (AT)
- Hospital of the Brothers of St. John of God (AT)
Publication Details
- Journal
- Clinical Chemistry and Laboratory Medicine (CCLM)
- Published
- 2025-03-14
- DOI
- https://doi.org/10.1515/cclm-2025-0115
- Primary Topic
- Chronic Lymphocytic Leukemia Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00