Exploring the Chemical Space of <i>Paenibacillus</i> NRPs and Discovery of Paenilipoheptin B
A combination of genomic and metabolomic analyses paired with molecular networking was applied to a collection of <i>Paenibacillus</i> spp. to identify the producers of a little-studied class of lipopeptides known as paenilipoheptins. Mass spectrometry and NMR spectroscopy allowed revision of the structure of previously reported paenilipoheptin A and elucidation of the structure of novel paenilipoheptin B.
Authors
- Nataliia V. Machushynets (ORCID: https://orcid.org/0000-0002-8530-1966)
- Somayah S. Elsayed (ORCID: https://orcid.org/0000-0003-3837-6137)
- Mark R. Liles (ORCID: https://orcid.org/0000-0002-9313-8150)
- Cornelis J. Slingerland (ORCID: https://orcid.org/0000-0003-0027-7491)
- Chao Du (ORCID: https://orcid.org/0000-0003-3447-5293)
- Nathaniel I. Martin (ORCID: https://orcid.org/0000-0001-8246-3006)
- Gilles P. van Wezel (ORCID: https://orcid.org/0000-0003-0341-1561)
- Vladyslav Lysenko (ORCID: https://orcid.org/0000-0001-9236-5821)
Institutions
- Leiden University (NL)
- Netherlands Institute of Ecology (NL)
- Auburn University (US)
Publication Details
- Journal
- Organic Letters
- Published
- 2025-03-14
- DOI
- https://doi.org/10.1021/acs.orglett.5c00231
- Citations
- 5
- Primary Topic
- Microbial Natural Products and Biosynthesis
- Type
- article
- Field-Weighted Citation Impact
- 5.58
Funders
- Nederlandse Organisatie voor Wetenschappelijk Onderzoek