<i>Candida albicans</i> : A Comprehensive View of the Proteome
We describe a new release of the <i>Candida albicans</i> PeptideAtlas proteomics spectral resource (build 2024-03), providing a sequence coverage of 79.5% at the canonical protein level, matched mass spectrometry spectra, and experimental evidence identifying 3382 and 536 phosphorylated serine and threonine sites with false localization rates of 1% and 5.3%, respectively. We provide a tutorial on how to use the PeptideAtlas and associated tools to access this information. The <i>C. albicans</i> PeptideAtlas summary web page provides "Build overview", "PTM coverage", "Experiment contribution", and "Data set contribution" information. The protein and peptide information can also be accessed via the <i>Candida</i> Genome Database via hyperlinks on each protein page. This allows users to peruse identified peptides, protein coverage, post-translational modifications (PTMs), and experiments that identify each protein. Given the value of understanding the PTM landscape in the sequence of each protein, a more detailed explanation of how to interpret and analyze PTM results is provided in the PeptideAtlas of this important pathogen. <i>Candida albicans</i> PeptideAtlas web page: https://db.systemsbiology.net/sbeams/cgi/PeptideAtlas/buildDetails?atlas_build_id=578.
Authors
- Gloria Molero (ORCID: https://orcid.org/0000-0001-5084-4111)
- Concha Gil (ORCID: https://orcid.org/0000-0003-3137-2600)
- Lucía Monteoliva (ORCID: https://orcid.org/0000-0003-4949-0664)
- Robert L. Moritz (ORCID: https://orcid.org/0000-0002-3216-9447)
- Eric W. Deutsch (ORCID: https://orcid.org/0000-0001-8732-0928)
- Ana Borrajo (ORCID: https://orcid.org/0000-0003-4939-0890)
- Zhi Sun (ORCID: https://orcid.org/0000-0003-3324-6851)
- Aída Pitarch (ORCID: https://orcid.org/0000-0002-3442-7876)
- Samuel de la Cámara Fuentes (ORCID: https://orcid.org/0000-0001-6718-5896)
- María Luisa Hernáez (ORCID: https://orcid.org/0000-0001-7292-1288)
- Leticia Gomez-Artiguez
Institutions
- Universidad Complutense de Madrid (ES)
- North Seattle College (US)
- Institute for Systems Biology (US)
- Abterra Biosciences (United States) (US)
Publication Details
- Journal
- Journal of Proteome Research
- Published
- 2025-03-14
- DOI
- https://doi.org/10.1021/acs.jproteome.4c01020
- Citations
- 1
- Primary Topic
- Antifungal resistance and susceptibility
- Type
- article
- Field-Weighted Citation Impact
- 1.40
Funders
- National Science Foundation
- Comunidad de Madrid
- Ministerio de Ciencia, Tecnología e Innovación Productiva
- National Institutes of Health
- Agencia Estatal de Investigación