Pharmacological inhibition of MutT homolog 1 (MTH1) in allergic airway inflammation as a novel treatment strategy
MTH1 inhibition reduced proliferation and promoted apoptosis of T cells in vitro. In vivo, TH1579 dampened the type 2 associated immune response in a murine model. These findings suggest that MTH1 could serve as a novel target to treat allergic airway inflammation.
Authors
- Arne Egesten (ORCID: https://orcid.org/0000-0001-5269-3433)
- Robin Kahn (ORCID: https://orcid.org/0000-0002-3167-1179)
- Tobias Schmidt (ORCID: https://orcid.org/0000-0001-9943-4121)
- Anna Adler (ORCID: https://orcid.org/0000-0002-9043-9599)
- Madelene W. Dahlgren (ORCID: https://orcid.org/0000-0002-8640-0157)
- Ulrika Warpman Berglund (ORCID: https://orcid.org/0000-0002-6372-1396)
- Praveen Papareddy (ORCID: https://orcid.org/0000-0002-3872-478X)
- Médea Padra (ORCID: https://orcid.org/0000-0001-7089-2188)
- Jesper Bergwik (ORCID: https://orcid.org/0000-0002-0737-2232)
Institutions
- Lund University (SE)
- Science for Life Laboratory (SE)
- Karolinska Institutet (SE)
- TeXtreme (Sweden) (SE)
- Wallenberg Wood Science Center (SE)
- Skåne University Hospital (SE)
Publication Details
- Journal
- Respiratory Research
- Published
- 2025-03-14
- DOI
- https://doi.org/10.1186/s12931-025-03175-z
- Citations
- 1
- Primary Topic
- Asthma and respiratory diseases
- Type
- article
- Field-Weighted Citation Impact
- 1.16
Funders
- Lunds Universitet