The protective role of cannabidiol in stress-induced liver injury: modulating oxidative stress and mitochondrial damage
CBD activates the CB<sub>2</sub>R/α-SMA pathway to modulate liver inflammation and fibrosis. Through the SLC7A11/ACSL4 signaling pathway, CBD alleviates oxidative stress in stress-induced liver injury, enhances mitochondrial morphology, and reduces liver damage. These findings provide a theoretical basis for the potential application of CBD in the prevention and treatment of stress-induced liver injury.
Authors
- J Wang (ORCID: https://orcid.org/0009-0000-5879-6521)
- C. F. Huang (ORCID: https://orcid.org/0000-0001-7506-5771)
- Yueyi Liu
- Xinhui Kou (ORCID: https://orcid.org/0000-0002-7662-6689)
- Haoran Jiang (ORCID: https://orcid.org/0000-0002-4792-6607)
- Xiaohua Liang (ORCID: https://orcid.org/0000-0003-3867-9779)
- Jun Chen (ORCID: https://orcid.org/0000-0002-3850-4875)
- Lili Huang (ORCID: https://orcid.org/0000-0002-4486-3532)
- Huichao Liang
Institutions
- Guangzhou University of Chinese Medicine (CN)
- Guangdong Pharmaceutical University (CN)
- Shenzhen Pingle Orthopedic Hospital (CN)
Publication Details
- Journal
- Frontiers in Pharmacology
- Published
- 2025-03-14
- DOI
- https://doi.org/10.3389/fphar.2025.1567210
- Citations
- 6
- Primary Topic
- Cannabis and Cannabinoid Research
- Type
- article
- Field-Weighted Citation Impact
- 8.37