The impact of co-occurring tumor suppressor mutations with mEGFR as early indicators of relapse in lung cancer
A set of 17 co-occurring TSG mutations has been identified as key biomarkers for early relapse in mEGFR lung adenocarcinoma. Longitudinal genomic monitoring, with a focus on clonal evolution, offers valuable insights that can inform personalized treatment strategies and potentially improve patient outcomes.
Authors
- Mitul Shah (ORCID: https://orcid.org/0000-0003-0239-2581)
- K. Prabhash
- Rajiv Chowdhury (ORCID: https://orcid.org/0000-0003-4881-5690)
- Abdur Rahman Hamidullah Chaudhary
- Nandini Menon
- Sajjad Ahmad (ORCID: https://orcid.org/0000-0003-0754-1742)
- Atul Bharde
- Jayant Khandare (ORCID: https://orcid.org/0000-0002-7301-3107)
- Deepika Lakhwani
- Vanita Noronha
- Anuradha Choughule (ORCID: https://orcid.org/0000-0002-9889-2136)
- Pratik Chandrani (ORCID: https://orcid.org/0000-0003-2572-0189)
- Saral Desai (ORCID: https://orcid.org/0000-0003-4692-1414)
- Amit Joshi (ORCID: https://orcid.org/0000-0001-8287-8375)
- Amit Dutt (ORCID: https://orcid.org/0000-0002-1119-4774)
- Sami Saqf el Hait
- Bhargavi Bawaskar
- Gowhar Shafi (ORCID: https://orcid.org/0000-0002-5606-800X)
- Vijay Patil (ORCID: https://orcid.org/0000-0003-2035-5215)
- Ganesh Dahimbekar
Institutions
- University of Delhi (IN)
- Homi Bhabha National Institute (IN)
- Tata Memorial Hospital (IN)
- Advanced Centre for Treatment, Research and Education in Cancer (IN)
Publication Details
- Journal
- ESMO Open
- Published
- 2025-03-14
- DOI
- https://doi.org/10.1016/j.esmoop.2025.104479
- Primary Topic
- Lung Cancer Treatments and Mutations
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Indian Council of Medical Research
- Science and Engineering Research Board
- Tata Memorial Centre
- Advanced Centre for Treatment, Research and Education in Cancer