Regional Brain Metabolism across the Alzheimer's Disease Continuum in Down Syndrome
The brain metabolic decline in DS with age reflects Alzheimer's pathological processes and involves temporoparietal regions in a similar pattern to that found in other forms of AD. Hypometabolism is more tightly related to CSF NfL levels than to core AD biomarkers. ANN NEUROL 2025;98:163-173.
Authors
- Valle Camacho (ORCID: https://orcid.org/0000-0003-0748-0847)
- Olivia Belbin (ORCID: https://orcid.org/0000-0002-6109-6371)
- Juan Fortea (ORCID: https://orcid.org/0000-0002-1340-638X)
- Alberto Lleó (ORCID: https://orcid.org/0000-0002-2568-5478)
- Laura del Hoyo Soriano (ORCID: https://orcid.org/0000-0003-4372-1599)
- Bessy Benejam (ORCID: https://orcid.org/0000-0002-6789-8615)
- Albert Flotats (ORCID: https://orcid.org/0000-0002-0469-827X)
- Íñigo Rodríguez‐Baz (ORCID: https://orcid.org/0000-0003-3039-9115)
- Laura Videla (ORCID: https://orcid.org/0000-0002-9748-8465)
- Lídia Vaqué‐Alcázar (ORCID: https://orcid.org/0000-0002-6776-6559)
- Isabel Barroeta (ORCID: https://orcid.org/0000-0003-2764-7923)
- Sára E. Zsadanyi (ORCID: https://orcid.org/0000-0002-2033-5989)
- María Carmona‐Iragui (ORCID: https://orcid.org/0000-0001-6914-2339)
- José Enrique Arriola‐Infante (ORCID: https://orcid.org/0000-0002-3298-4601)
- Lucía Maure-Blesa (ORCID: https://orcid.org/0000-0001-5643-7971)
- Sandra Giménez (ORCID: https://orcid.org/0000-0001-8031-2319)
- Alexandre Bejanin (ORCID: https://orcid.org/0000-0002-9958-0951)
- Alejandra O. Morcillo‐Nieto (ORCID: https://orcid.org/0000-0003-2202-3521)
- Daniel Andres Alcolea (ORCID: https://orcid.org/0000-0002-3819-3245)
- Mateus Rozalem‐Aranha
- Susana Fernández (ORCID: https://orcid.org/0000-0002-3219-065X)
- Javier Arranz (ORCID: https://orcid.org/0000-0003-0891-1215)
- María Franquesa‐Mullerat (ORCID: https://orcid.org/0009-0006-1484-7132)
- Aida Sanjuan‐Hernández
Institutions
- Universitat Autònoma de Barcelona (ES)
- Hospital de Sant Pau (ES)
- Biomedical Research Networking Center on Neurodegenerative Diseases (ES)
- Consorci Institut D'Investigacions Biomediques August Pi I Sunyer (ES)
- Universitat de Barcelona (ES)
Publication Details
- Journal
- Annals of Neurology
- Published
- 2025-03-14
- DOI
- https://doi.org/10.1002/ana.27226
- Citations
- 3
- Primary Topic
- Down syndrome and intellectual disability research
- Type
- article
- Field-Weighted Citation Impact
- 5.64
Funders
- Alzheimer's Association
- BrightFocus Foundation
- Global Brain Health Institute
- Fondation Jérôme Lejeune
- Fundación Tatiana Pérez de Guzmán el Bueno
- Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas
- National Institutes of Health
- Instituto de Salud Carlos III