Aged and <i>BRCA</i> -Mutated Stromal Cells Drive Epithelial Cell Transformation
This work demonstrates a critical role of fallopian tube stromal cells in HGSOC initiation with implications for the pathophysiology of HGSOC formation and the development of prevention and early detection strategies critically needed in this disease. Additionally, the identification of stromal-mediated epithelial transformation has broad implications for understanding pan-cancer initiation. See related commentary by Recouvreux and Orsulic, p. 1093.
Authors
- Roja Baruwal (ORCID: https://orcid.org/0000-0002-2947-9057)
- Geyon L. Garcia (ORCID: https://orcid.org/0000-0002-3918-2724)
- Toren Finkel (ORCID: https://orcid.org/0000-0002-0726-3546)
- Huda I. Atiya (ORCID: https://orcid.org/0000-0001-9850-102X)
- Amal T. Elhaw (ORCID: https://orcid.org/0000-0001-6547-3018)
- Hui Shen (ORCID: https://orcid.org/0000-0001-9767-4084)
- Leonard Frisbie (ORCID: https://orcid.org/0000-0001-8996-4292)
- Nadine Hempel (ORCID: https://orcid.org/0000-0002-5574-8783)
- Riyue Bao (ORCID: https://orcid.org/0000-0002-6105-1704)
- Lan Coffman (ORCID: https://orcid.org/0000-0002-3753-1652)
- T. Rinda Soong (ORCID: https://orcid.org/0000-0002-1565-992X)
- Ian Beddows (ORCID: https://orcid.org/0000-0001-7403-0016)
- Swathi Suresh
- Taylor Orellana (ORCID: https://orcid.org/0000-0002-8132-3455)
- Brian R. Isett (ORCID: https://orcid.org/0000-0002-1581-0706)
- Tullia C. Bruno (ORCID: https://orcid.org/0000-0002-6433-0207)
- Grace Gorecki (ORCID: https://orcid.org/0000-0002-4001-5528)
- Ronald J. Buckanovich (ORCID: https://orcid.org/0000-0002-5665-9790)
- Ronny Drapkin (ORCID: https://orcid.org/0000-0002-6912-6977)
- Ian MacFawn (ORCID: https://orcid.org/0000-0001-9056-1255)
- Ester Goldfeld (ORCID: https://orcid.org/0000-0001-8998-8788)
- Ananya K. Britt
- Macy M. Hale (ORCID: https://orcid.org/0000-0003-2243-825X)
Institutions
- Pennsylvania State University (US)
- Van Andel Institute (US)
- Medical University of South Carolina (US)
- University of Pittsburgh (US)
- Grove City College (US)
- University of Colorado Boulder (US)
- Point Park University (US)
- University of Virginia Health System (US)
- Magee-Womens Research Institute (US)
- UPMC Hillman Cancer Center (US)
- University of Pittsburgh Medical Center (US)
- University of Pennsylvania (US)
- Penn State Milton S. Hershey Medical Center (US)
Publication Details
- Journal
- Cancer Discovery
- Published
- 2025-03-14
- DOI
- https://doi.org/10.1158/2159-8290.cd-24-0805
- Citations
- 6
- Primary Topic
- Ovarian cancer diagnosis and treatment
- Type
- article
- Field-Weighted Citation Impact
- 10.19