Development of Anti-CEA CH2 Domain-Deleted Antibody (M5A∆CH2) for the PET Imaging of Colorectal Cancer
A series of humanized anti-CEA M5A∆C<sub>H</sub>2 antibodies were designed for immunoPET imaging of colorectal cancer, and the [<sup>64</sup>Cu]Cu-DO3A-M5A∆C<sub>H</sub>2-C5 showed high tumor targeting and fast blood clearance supporting its potential for clinical trials.
Authors
- Paul J. Yazaki (ORCID: https://orcid.org/0000-0003-2626-3303)
- John E. Shively (ORCID: https://orcid.org/0000-0002-7763-770X)
- Maciej Kujawski (ORCID: https://orcid.org/0000-0002-9701-5211)
- Anakim Sherman
- Eric Aniogo
- Teresa Hong
- Patty Wong
- Jitender Jitender
Institutions
- City Of Hope National Medical Center (US)
- City of Hope (US)
- Theranostics (New Zealand) (NZ)
- Molecular Theranostics (United States) (US)
Publication Details
- Journal
- Molecular Imaging and Biology
- Published
- 2025-03-14
- DOI
- https://doi.org/10.1007/s11307-025-01997-3
- Primary Topic
- Monoclonal and Polyclonal Antibodies Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- City of Hope