Amino acid variants in the HLA-DQA1 and HLA-DQB1 molecules explain the major association of variants with relapse status in pediatric patients with steroid-sensitive nephrotic syndrome
rs1464545187 is a risk locus for SSNSWR but not SDNS/FRNS in Chinese children. Functional variations in HLA-DQA1 and HLA-DQB1 are implicated in regulating the immune response of SSNS patients, which may explain the typical triggering of SDNS/FRNS onset by infections.
Authors
- Sijie Yu
- Haiping Yang (ORCID: https://orcid.org/0000-0002-4245-9376)
- Mo Wang (ORCID: https://orcid.org/0000-0001-7004-3549)
- Qiu Li (ORCID: https://orcid.org/0000-0002-2481-7168)
- Hui Yin
- Xuelan Chen
- Han Chan
Institutions
- Children's Hospital of Chongqing Medical University (CN)
- Chongqing Medical University (CN)
Publication Details
- Journal
- The Italian Journal of Pediatrics/Italian journal of pediatrics
- Published
- 2025-03-14
- DOI
- https://doi.org/10.1186/s13052-025-01913-z
- Primary Topic
- Renal Diseases and Glomerulopathies
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China