Alstolarsines A–E, Indoline Alkaloids with Two Different Carbon Skeletons from <i>Alstonia scholaris</i>
Five complex indoline alkaloids, alstolarsines A-E (<b>1</b>-<b>5</b>) possessing two unprecedented carbon skeletons of 6/5/5/7/6/6(5) fused polycyclic systems, were isolated from <i>Alstonia scholaris</i>. Their structures were characterized using various methods including spectroscopic data, ECD spectra, and single-crystal X-ray diffraction. The inhibitory activities of alstolarsines A-D (<b>1</b>-<b>4</b>) on DRAK2 phosphorylation and ATP-citrate lyase were evaluated, but all of them were inactive.
Authors
- Yao‐Yue Fan (ORCID: https://orcid.org/0000-0003-1387-202X)
- Xu-Xin Zhu
- Jian‐Min Yue (ORCID: https://orcid.org/0000-0002-4053-4870)
- Cheng‐Yu Zheng (ORCID: https://orcid.org/0000-0003-0802-849X)
- Hongying Yang (ORCID: https://orcid.org/0000-0003-0246-2797)
- Kun Gao (ORCID: https://orcid.org/0000-0002-3856-3672)
Institutions
- Chinese Academy of Sciences (CN)
- Shanghai Institute of Materia Medica (CN)
- Lanzhou University (CN)
Publication Details
- Journal
- Journal of Natural Products
- Published
- 2025-03-14
- DOI
- https://doi.org/10.1021/acs.jnatprod.5c00027
- Citations
- 3
- Primary Topic
- Alkaloids: synthesis and pharmacology
- Type
- article
- Field-Weighted Citation Impact
- 4.67
Funders
- National Natural Science Foundation of China
- Shanghai Rising-Star Program