The thrombin generation potential increases after feminizing gender-affirming hormone treatment, decreases after masculinizing gender-affirming hormone treatment, and is determined by the hormone treatment regimen
Feminizing and masculinizing GAHT for 12 months affected coagulation in opposite directions. Feminizing GAHT was procoagulant, whereas masculinizing GAHT was anticoagulant. Of note, transdermal feminizing GAHT had the least pronounced procoagulant effect.
Authors
- Chantal M Wiepjes (ORCID: https://orcid.org/0000-0002-8280-0065)
- Guy G. T'Sjoen (ORCID: https://orcid.org/0000-0003-0457-9673)
- Louise Lehmann Christensen (ORCID: https://orcid.org/0000-0001-6489-7054)
- Else‐Marie Bladbjerg (ORCID: https://orcid.org/0000-0003-0912-2437)
- Dorte Glintborg (ORCID: https://orcid.org/0000-0002-8338-8025)
- Marianne Andersen (ORCID: https://orcid.org/0000-0002-4603-9504)
- Mette Bøgehave (ORCID: https://orcid.org/0000-0001-8523-2078)
- Martin den Heijer (ORCID: https://orcid.org/0000-0003-3620-5617)
- Jeroen Vervalcke
Institutions
- University of Southern Denmark (DK)
- Ghent University Hospital (BE)
- Odense University Hospital (DK)
- Gender Studies (CZ)
- Hospital South West Jutland (DK)
- Amsterdam University Medical Centers (NL)
Publication Details
- Journal
- Journal of Thrombosis and Haemostasis
- Published
- 2025-03-14
- DOI
- https://doi.org/10.1016/j.jtha.2025.03.006
- Citations
- 4
- Primary Topic
- Sex and Gender in Healthcare
- Type
- article
- Field-Weighted Citation Impact
- 7.51
Funders
- Syddansk Universitet