Heart ketone metabolism under acute ketone supplementation in ZDF rats, a type 2 diabetes heart failure model
In a rat model of T2D and CFR impairment, we were able to measure changes in ketone metabolism using [<sup>11</sup>C]AcAc PET at rest and under stress with and without acute ketone supplementation. Our findings suggest that the heart ketone metabolism of T2D rats is impaired during the heart failure process. Ketone supplementation may have the potential to restore this cardiac reserve.
Authors
- Roger Lecomte (ORCID: https://orcid.org/0000-0002-8541-0783)
- Gabriel Richard (ORCID: https://orcid.org/0000-0002-5195-4870)
- Brigitte Guérin (ORCID: https://orcid.org/0000-0002-0319-4512)
- Patrick Prud’Homme
- Véronique Dumulon‐Perreault
- Étienne Croteau (ORCID: https://orcid.org/0000-0002-4971-6443)
- Otman Sarrhini (ORCID: https://orcid.org/0000-0001-6231-2630)
- Serge Phoenix (ORCID: https://orcid.org/0009-0003-5697-0655)
- Stephen C. Cunnane (ORCID: https://orcid.org/0000-0003-4003-9762)
- Étienne Rousseau (ORCID: https://orcid.org/0000-0002-2394-7446)
- Sébastien Tremblay (ORCID: https://orcid.org/0000-0002-1347-6329)
Institutions
- Université de Sherbrooke (CA)
Publication Details
- Journal
- EJNMMI Research
- Published
- 2025-03-14
- DOI
- https://doi.org/10.1186/s13550-025-01215-9
- Primary Topic
- Diet and metabolism studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00