PDE4 Inhibition Reduced Osteoclast Differentiation in Psoriatic Patients
Our findings highlight the role of PDE4 in the pro-osteoclastogenic process in psoriasis and suggest that apremilast may counteract bone resorption by modulating RANKL levels and osteoclast differentiation, with potential clinical implications.
Authors
- Alessia Balestrino (ORCID: https://orcid.org/0009-0007-1982-7031)
- Annunziata Raimondo (ORCID: https://orcid.org/0000-0002-0849-715X)
- Serena Lembo (ORCID: https://orcid.org/0000-0001-9053-1793)
Institutions
- University of Salerno (IT)
Publication Details
- Journal
- Life
- Published
- 2025-03-14
- DOI
- https://doi.org/10.3390/life15030467
- Primary Topic
- Psoriasis: Treatment and Pathogenesis
- Type
- article
- Field-Weighted Citation Impact
- 0.00