Combining exchangeable <i>P</i> -values

The problem of combining <i>P</i>-values is an old and fundamental one, and the classic assumption of independence is often violated or unverifiable in many applications. There are many well-known rules that can combine a set of arbitrarily dependent <i>P</i>-values (for the same hypothesis) into a single <i>P</i>-value. We show that essentially all these existing rules can be strictly improved when the <i>P</i>-values are exchangeable, or when external randomization is allowed (or both). For example, we derive randomized and/or exchangeable improvements of well-known rules like "twice the median" and "twice the average," as well as geometric and harmonic means. Exchangeable <i>P</i>-values are often produced one at a time (for example, under repeated tests involving data splitting), and our rules can combine them sequentially as they are produced, stopping when the combined <i>P</i>-values stabilize. Our work also improves rules for combining arbitrarily dependent <i>P</i>-values, since the latter becomes exchangeable if they are presented to the analyst in a random order. The main technical advance is to show that all existing combination rules can be obtained by calibrating the <i>P</i>-values to e-values (using an [Formula: see text]-dependent calibrator), averaging those e-values, converting to a level-[Formula: see text] test using Markov's inequality, and finally obtaining <i>P</i>-values by combining this family of tests; the improvements are delivered via recent randomized and exchangeable variants of Markov's inequality.

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Publication Details

Journal
Proceedings of the National Academy of Sciences
Published
2025-03-14
DOI
https://doi.org/10.1073/pnas.2410849122
Citations
3
Primary Topic
Statistical Methods in Clinical Trials
Type
article
Field-Weighted Citation Impact
7.89

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article

Combining exchangeable P -values

Aaditya Ramdas, Ruodu Wang, Matteo Gasparin
3 citations
Proceedings of the National Academy of Sciences
Statistical Methods in Clinical Trials
7.89
article

Combining exchangeable P -values

Aaditya Ramdas, Ruodu Wang, Matteo Gasparin
article en
3 citations

Abstract

The problem of combining <i>P</i>-values is an old and fundamental one, and the classic assumption of independence is often violated or unverifiable in many applications. There are many well-known rules that can combine a set of arbitrarily dependent <i>P</i>-values (for the same hypothesis) into a single <i>P</i>-value. We show that essentially all these existing rules can be strictly improved when the <i>P</i>-values are exchangeable, or when external randomization is allowed (or both). For example, we derive randomized and/or exchangeable improvements of well-known rules like "twice the median" and "twice the average," as well as geometric and harmonic means. Exchangeable <i>P</i>-values are often produced one at a time (for example, under repeated tests involving data splitting), and our rules can combine them sequentially as they are produced, stopping when the combined <i>P</i>-values stabilize. Our work also improves rules for combining arbitrarily dependent <i>P</i>-values, since the latter becomes exchangeable if they are presented to the analyst in a random order. The main technical advance is to show that all existing combination rules can be obtained by calibrating the <i>P</i>-values to e-values (using an [Formula: see text]-dependent calibrator), averaging those e-values, converting to a level-[Formula: see text] test using Markov's inequality, and finally obtaining <i>P</i>-values by combining this family of tests; the improvements are delivered via recent randomized and exchangeable variants of Markov's inequality.

Proceedings of the National Academy of SciencesVol. 122(11)
University of Padua (IT), University of Waterloo (CA), Carnegie Mellon University (US)
National Science Foundation, Alfred P. Sloan Foundation, Canada Research Chairs, Natural Sciences and Engineering Research Council of Canada, Division of Mathematical Sciences
Openalex Percentile: Top 3%
Statistical Methods in Clinical Trials
7.89
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