Effect of Low-Frequency Magnetic Field Stimulation on Physical Performance and Inflammation in Post-Stroke Patients: A Feasibility and Safety Study

Background: Strokes are a major public health concern, responsible for high mortality and long-term disability rates. Rehabilitation techniques aim to harness neuroplasticity—brain self-repair mechanisms that restore lost functions. Beyond traditional methods, therapies like Repetitive Transcranial Magnetic Stimulation (rTMS) and Extremely Low-Frequency Magnetic Fields (ELF-MFs) show promise in enhancing neuroplasticity. This pilot study explored the feasibility and safety of ELF-MFs in stroke rehabilitation. Methods: The study involved 44 patients randomized into three groups: magnetotherapy applied to the head (MT1), pelvis (MT2), or standard rehabilitation (control). Assessments included functional measures (FIM, Barthel Index, Tinetti Scale, SPPB, and Berg Balance Scale) and inflammatory markers (CRP, PCT). Results: All groups showed functional improvement, with CRP and PCT reductions highlighting potential benefits of ELF-MFs. No adverse effects or changes in blood or organ function were observed. Conclusions: ELF-MFs could be safely conducted in this group allowing for further research to confirm their efficacy in larger studies.