Sirtuin1 mitigates hypoxia-induced cardiomyocyte apoptosis in myocardial infarction via PHD3/HIF-1α
Sirt1 effectively reduces cardiomyocyte apoptosis and myocardial infarction size while enhancing cardiac function post-MI, primarily through the Phd3/Hif-1α signaling pathway.
Authors
- Ke Yang (ORCID: https://orcid.org/0000-0002-1870-1134)
- Yafen Chen
- Qihong Wu (ORCID: https://orcid.org/0000-0002-8625-0777)
- Jiawei Chen (ORCID: https://orcid.org/0000-0001-5383-1359)
- Yan Ren (ORCID: https://orcid.org/0000-0001-8854-6283)
- Shuyao Shan
- Jiumei Cao
- Qiqi Xue
Institutions
- Sun Yat-sen University (CN)
- Fudan University (CN)
- Ruijin Hospital (CN)
- Zhongshan Hospital (CN)
- The First Affiliated Hospital, Sun Yat-sen University (CN)
Publication Details
- Journal
- Molecular Medicine
- Published
- 2025-03-14
- DOI
- https://doi.org/10.1186/s10020-025-01155-z
- Citations
- 8
- Primary Topic
- Autophagy in Disease and Therapy
- Type
- article
- Field-Weighted Citation Impact
- 10.83
Funders
- Natural Science Foundation of Shanghai
- National Natural Science Foundation of China
- Shanghai Jiao Tong University