Euphthymifolols A-E, anti-inflammatory jatrophane-type macrocyclic diterpenoids from <i>Euphorbia thymifolia</i> L
Euphthymifolols A-E (<b>1</b>-<b>5</b>), five undescribed jatrophane diterpenoids feature with a typically 5/12 bicyclic skeleton, were characterised from the aerial parts of <i>Euphorbia thymifolia</i> L. A thorough analysis of the spectroscopic data and biosynthetic pathway elucidated their planar structures and stereoconfiguration. Compound <b>4</b> exhibited moderate nitric oxide (NO) inhibitory activity (IC<sub>50</sub> 63.3 ± 1.94 μM) against LPS-induced BV-2 microglia cells.
Authors
- Zhipeng Deng (ORCID: https://orcid.org/0009-0008-7550-2861)
- Pan Zhao (ORCID: https://orcid.org/0000-0003-1797-8024)
- C.-C. Liang
- Yangyang Liu (ORCID: https://orcid.org/0000-0001-8547-0172)
- Shijun Wang (ORCID: https://orcid.org/0000-0002-5654-8118)
- Jiangying Cao (ORCID: https://orcid.org/0000-0002-8824-8654)
Institutions
- Shandong University of Traditional Chinese Medicine (CN)
Publication Details
- Journal
- Natural Product Research
- Published
- 2025-03-14
- DOI
- https://doi.org/10.1080/14786419.2025.2478303
- Citations
- 1
- Primary Topic
- Bioactive Natural Diterpenoids Research
- Type
- article
- Field-Weighted Citation Impact
- 0.81
Funders
- Natural Science Foundation of Shandong Province