Association of serum anti-gbs2106 protein immunoglobulin G (IgG) in newborns and risk reduction of invasive group B streptococcus disease during early infancy.
Our study demonstrates an inverse association between infant serum anti-gbs2106 IgG and risk of invasive GBS disease, indicating gbs2106 protein as a potential vaccine candidate.
Authors
- Gaurav Kwatra (ORCID: https://orcid.org/0009-0008-2032-1975)
- Nisha Dhar (ORCID: https://orcid.org/0000-0002-7964-5818)
- Carmen Briner
- Alane Izu (ORCID: https://orcid.org/0000-0002-5547-7223)
- Shabir Ahmed Madhi (ORCID: https://orcid.org/0000-0002-7629-0636)
- Nancy Hosken (ORCID: https://orcid.org/0000-0003-2680-3533)
- Ziyaad Dangor (ORCID: https://orcid.org/0000-0003-4089-147X)
- Vicky Gent
- Stephanie Jones
Institutions
- South African Medical Research Council (ZA)
- Program for Appropriate Technology in Health (US)
- Christian Medical College, Vellore (IN)
- University of the Witwatersrand (ZA)
- University of Cincinnati Medical Center (US)
Publication Details
- Journal
- Vaccine
- Published
- 2025-03-14
- DOI
- https://doi.org/10.1016/j.vaccine.2025.127016
- Citations
- 1
- Primary Topic
- Neonatal and Maternal Infections
- Type
- article
- Field-Weighted Citation Impact
- 1.88
Funders
- Bill and Melinda Gates Foundation
- Pfizer
- GlaxoSmithKline
- Ernest Oppenheimer Memorial Trust