Unraveling tumoral heterogeneity and angiogenesis-associated mechanisms of PD-1 and LAG-3 dual inhibition in lung cancers by single-cell RNA sequencing
We discovered the superior efficacy of PD-1 and LAG-3 dual inhibition in SCC PDX models, and showed that it may be associated with low tumor heterogeneity scores, upregulation of the MHC class I pathway, and normalization of tumor angiogenesis.
Authors
- Kandi Xu
- Wengang Zhang (ORCID: https://orcid.org/0000-0001-6051-1388)
- Wencheng Zhao (ORCID: https://orcid.org/0000-0001-5544-781X)
- Lishu Zhao (ORCID: https://orcid.org/0000-0003-4728-9107)
- Yayi He (ORCID: https://orcid.org/0000-0002-2820-9119)
- Ye Li (ORCID: https://orcid.org/0009-0007-2534-7552)
- Zhimin Chen (ORCID: https://orcid.org/0000-0003-3942-9579)
- Hao Wang (ORCID: https://orcid.org/0000-0002-9971-1237)
- Qi Liu (ORCID: https://orcid.org/0000-0002-3007-7012)
- Yujin Liu (ORCID: https://orcid.org/0000-0002-0114-7421)
- Xuan Jin
- Chen Tang (ORCID: https://orcid.org/0000-0002-3411-0078)
- Xinyue Liu (ORCID: https://orcid.org/0000-0002-4094-3033)
Institutions
- Tongji University (CN)
- Shanghai Pulmonary Hospital (CN)
Publication Details
- Journal
- Chinese Medical Journal - Pulmonary and Critical Care Medicine
- Published
- 2025-03-01
- DOI
- https://doi.org/10.1016/j.pccm.2025.02.004
- Citations
- 1
- Primary Topic
- Cancer Immunotherapy and Biomarkers
- Type
- article
- Field-Weighted Citation Impact
- 1.05