Single-cell and spatial transcriptomics analysis reveals that Pros1 oligodendrocytes are involved in endogenous neuroprotection after brainstem stroke
In conclusion, we identified a novel cell subcluster, OLG8 cells, in the context of brainstem stroke, and found that overexpression of Myo1e alleviated ischemic injury by facilitating the differentiation of OLG8 cells. Our study provided insight into the mechanism of brainstem stroke.
Authors
- Yongjun Jiang (ORCID: https://orcid.org/0009-0002-6420-8604)
- Ming Luo (ORCID: https://orcid.org/0000-0003-2281-8324)
- Li Wu
- Zhihua Qiu (ORCID: https://orcid.org/0000-0002-3446-1492)
- Jie Li
- Shaojun Li (ORCID: https://orcid.org/0000-0002-3547-915X)
- Chenxi Pang
- Guanfeng Zeng
Institutions
- Second Affiliated Hospital of Guangzhou Medical University (CN)
- Guangzhou Medical University (CN)
Publication Details
- Journal
- Neurobiology of Disease
- Published
- 2025-03-15
- DOI
- https://doi.org/10.1016/j.nbd.2025.106855
- Citations
- 2
- Primary Topic
- Neuroinflammation and Neurodegeneration Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 1.68
Funders
- National Natural Science Foundation of China