Whole Genome Sequencing Analysis of <i>Klebsiella pneumoniae</i> Isolates from Health Care–Associated Bacteremia of Urinary Origin in Spain: Findings from the Multicenter ITUBRAS-2 Cohort Study
There is a high prevalence of 3GCR and <i>CR-Kp</i> causing HCA-BUO in Spain, mainly driven by the dissemination of ST307/CTX-M-15 and other globally spread multidrug-resistant high-risk clones, challenging the selection of empirical and targeted treatments for these infections.
Authors
- José Luís del Pozo (ORCID: https://orcid.org/0000-0002-5402-3334)
- Sílvia Gómez-Zorrilla (ORCID: https://orcid.org/0000-0002-5987-068X)
- Xavier Durán (ORCID: https://orcid.org/0000-0001-8517-9254)
- Patricia Ruíz-Garbajosa (ORCID: https://orcid.org/0000-0003-4795-0217)
- Mariona Xercavins (ORCID: https://orcid.org/0000-0003-1463-6344)
- Juan Pablo Horcajada (ORCID: https://orcid.org/0000-0001-9873-5459)
- Ana de Malet
- R. Ponz (ORCID: https://orcid.org/0009-0007-9027-3326)
- Rafael Cantón (ORCID: https://orcid.org/0000-0003-1675-3173)
- Ana Siverio
- Luis Canoura‐Fernández
- Dàmaris Berbel (ORCID: https://orcid.org/0000-0002-3689-3360)
- Alba Rivera (ORCID: https://orcid.org/0000-0002-9709-6162)
- Marta Hernández-García (ORCID: https://orcid.org/0000-0003-2857-2572)
- Federico Becerra-Aparicio (ORCID: https://orcid.org/0000-0002-0948-0958)
- Cristina Seral
- Paul G. Higgins (ORCID: https://orcid.org/0000-0001-8677-9454)
- Kyriaki Xanthopoulou (ORCID: https://orcid.org/0000-0001-8591-8184)
- Enrique Ruíz de Gopegui (ORCID: https://orcid.org/0000-0002-8752-6894)
- Manuel Cotarelo (ORCID: https://orcid.org/0000-0002-7017-0369)
- José Antonio Martínez
- Antonio Oliver (ORCID: https://orcid.org/0000-0001-9327-1894)
- Desiré Gijón
- Emilia Cercenado
Institutions
- Generalitat de Catalunya (ES)
- University of Cologne (DE)
- Instituto de Salud Carlos III (ES)
- Bellvitge University Hospital (ES)
- Hospital General Universitario Gregorio Marañón (ES)
- Centro de Investigación Biomédica en Red de Enfermedades Respiratorias (ES)
- Centro de Investigación Biomédica en Red (ES)
- Hospital Clínic de Barcelona (ES)
- German Center for Infection Research (DE)
- Health Research Institute of the Balearic Islands (ES)
- Instituto Ramón y Cajal de Investigación Sanitaria (ES)
- Mútua Terrassa (ES)
- Hospital Del Mar (ES)
- Hospital Clínico Universitario Lozano Blesa (ES)
- MSD (Spain) (ES)
- Hospital Universitario Lucus Augusti (ES)
- Hospital Universitario Son Espases (ES)
- University Hospital Cologne (DE)
- Hospital del Mar Research Institute (ES)
- Complejo Hospitalario de Pontevedra (ES)
- Instituto de Investigación de Enfermedades Raras (ES)
- Hospital Universitario Ramón y Cajal (ES)
- Universidad de Navarra (ES)
Publication Details
- Journal
- Open Forum Infectious Diseases
- Published
- 2025-03-15
- DOI
- https://doi.org/10.1093/ofid/ofaf164
- Primary Topic
- Antibiotic Resistance in Bacteria
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Pfizer
- Universitat Pompeu Fabra
- Shionogi
- Universitat Autònoma de Barcelona
- Sociedad Española de Enfermedades Infecciosas y Microbiología Clínica