Chitosan/hydroxyapatite biomimetic material loaded with <i>Curcuma longa L.</i> essential oil

Abstract In this work, Curcuma longa L. essential oil (CEO) was loaded into the modified chitosan/hydroxyapatite (PMCH) biomimetic material and the PMCH/CEO was characterized by FTIR, SEM, XRD and BET. The main components of CEO were ar-tumerone (21.97 %), ar-curcumene (13.00 %), β-sesquiphellandrene (13.00 %) and curlone (8.57 %), which was analyzed by GC-MS. The stability of PMCH/CEO was investigated at different relative humidities (33 % and 96 %) and temperatures (60 °C and 80 °C) conditions. The ability of CEO and PMCH/CEO to scavenge DPPH radicals and ABTS radicals is used to evaluate the antioxidant acivity. The concentration of the sample was determined by the CCK-8 method, and the lipopolysaccharide-induced RAW264.7 cell inflammation model was established to evaluate the anti-inflammatory effect. CEO and PMCH/CEO showed good antioxidant activity. CEO and PMCH/CEO also had significant inhibitory effects on NO, IL-6 and TNF-α, and the inhibition rates were 85.62 %, 55.82 % and 27.7 %, respectively. This study shows that CEO-loaded PMCH has potential development prospects in food, medicine and other related fields.