Effect of cumulative dexamethasone dose on the outcome of patients with radiosurgically treated brain metastases in the era of modern oncological therapy
A cumulative dexamethasone dose ≥ 100 mg within 30 days before and after radiosurgery was identified as an independent risk factor for death. Consequently, even in the modern oncological era, the recommendation to delay local BM treatment should be critically reviewed, as the main reason for dexamethasone treatment is the presence of neurological symptoms caused by larger BMs and perifocal edema. Thus, the study data support early local BM treatment to avoid dexamethasone treatment for neurological symptoms caused by progressive BMs.
Authors
- Philippe Dodier (ORCID: https://orcid.org/0000-0002-8850-8321)
- Martin Schreder (ORCID: https://orcid.org/0000-0002-1699-9715)
- Maximilian J. Hochmair (ORCID: https://orcid.org/0000-0002-8673-2450)
- Yiru Chen (ORCID: https://orcid.org/0000-0001-6202-740X)
- Lukas Haider (ORCID: https://orcid.org/0000-0002-1556-1770)
- Irene Kapfhammer
- Christian Dorfer (ORCID: https://orcid.org/0000-0002-1843-7732)
- Sabine Zöchbauer‐Müller (ORCID: https://orcid.org/0000-0002-6777-1729)
- Klaus Kirchbacher
- Josa M. Frischer (ORCID: https://orcid.org/0000-0002-6638-3476)
- Brigitte Gatterbauer (ORCID: https://orcid.org/0000-0002-3346-0236)
- Anna Cho (ORCID: https://orcid.org/0000-0002-5211-382X)
- Karl Rössler (ORCID: https://orcid.org/0000-0002-9249-8082)
- Tomasz Jankowski (ORCID: https://orcid.org/0000-0002-0049-7673)
- Sonja Tögl
Institutions
- Lenzing (Austria) (AT)
- Medical University of Vienna (AT)
Publication Details
- Journal
- Journal of neurosurgery
- Published
- 2025-03-14
- DOI
- https://doi.org/10.3171/2024.12.jns241771
- Citations
- 2
- Primary Topic
- Brain Metastases and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 3.04