A contemporary, multiinstitutional analysis of transcription factor lineage in pituitary adenomas: comparative study of neuroimaging, histopathology, and clinical outcomes
The modern WHO diagnosis of PAs incorporates pituitary TF staining to standardize classification according to PA cell lineage. TF designation is associated with major clinical and endocrine variables including PA extension, extrasellar growth patterns, Ki-67 labeling index, and PFS among patients with PA subtypes.
Authors
- Jacob Ruzevick
- Craig Horbinski (ORCID: https://orcid.org/0000-0001-8340-9992)
- John D. Carmichael (ORCID: https://orcid.org/0000-0002-3194-9249)
- Ilaria Bove (ORCID: https://orcid.org/0000-0003-3909-7420)
- Mark S. Shiroishi (ORCID: https://orcid.org/0000-0002-1422-0288)
- David J. Coté (ORCID: https://orcid.org/0000-0001-5419-1517)
- Anna Mathew
- Andrew S. Little (ORCID: https://orcid.org/0000-0002-1082-4471)
- Ben A. Strickland (ORCID: https://orcid.org/0000-0002-4620-9542)
- Dhiraj J. Pangal (ORCID: https://orcid.org/0000-0001-7391-9825)
- Edward R. Laws (ORCID: https://orcid.org/0000-0003-4804-9535)
- Norman E. Garrett
- Stephanie Kim Cheok (ORCID: https://orcid.org/0000-0002-1797-1124)
- Ana Valeria Castro (ORCID: https://orcid.org/0000-0003-1625-0015)
- Ishan Shah (ORCID: https://orcid.org/0009-0008-0910-5956)
- Robert G. Briggs (ORCID: https://orcid.org/0000-0001-9329-4471)
- Yana Zavros
- Gabriel Zada (ORCID: https://orcid.org/0000-0001-5821-902X)
- Jeffrey J. Feng (ORCID: https://orcid.org/0000-0001-6927-4083)
- Kyle Hurth (ORCID: https://orcid.org/0000-0003-0115-4610)
- David Gómez (ORCID: https://orcid.org/0000-0003-3612-661X)
Institutions
- Northwestern University (US)
- University of Southern California (US)
- Brigham and Women's Hospital (US)
- Barrow Neurological Institute (US)
- University of Arizona (US)
- University of Washington (US)
- Medical College of Wisconsin (US)
- Neurological Surgery (US)
- Michigan State University (US)
Publication Details
- Journal
- Journal of neurosurgery
- Published
- 2025-03-14
- DOI
- https://doi.org/10.3171/2024.10.jns24853
- Citations
- 2
- Primary Topic
- Pituitary Gland Disorders and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 2.59